systems medicine


The BMBF-funded DROP2AI project aims to predict drug response from transcriptomics and proteomics drug screens using state of the art AI methods.


Cancer driver drug interaction explorer for drug repurposing in oncology.


In the DFG-funded project DyHealthNet we build an explorative analysis platform for population cohorts.


The BMBF-funded NetfLID project aims to identify molecular mechanisms contributing to long-term consequences of viral infections by applying network medicine methods to rich molecular data.


REPO4EU is a euro-global platform for mechanism-based drug repurposing through real-world data and artificial intelligence covering every step from lab to phase II clinical.

BiCoN: Network-constrained biclustering of patients and omics data

**Motivation** Unsupervised learning approaches are frequently employed to identify patient subgroups and biomarkers such as disease-associated genes. Thus, clustering and biclustering are powerful techniques often used with expression data, but are …

Computational Strategies to Combat COVID-19: Useful Tools to Accelerate SARS-CoV-2 and Coronavirus Research

SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel virus of the family Coronaviridae. The virus causes the infectious disease COVID-19. The biology of coronaviruses has been studied for many years. However, bioinformatics tools …


Analyze protein-protein and domain-domain interactions in a joint graph.


Network-based functional enrichment of alternative splicing.

Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

Coronavirus Disease-2019 (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Various studies exist about the molecular mechanisms of viral infection. However, such information is spread across many publications and it is very …