EpiGEN: an epistasis simulation pipeline

Abstract

Simulated data is crucial for evaluating epistasis detection tools in genome-wide association studies. Existing simulators are limited, as they do not account for linkage disequilibrium (LD), support limited interaction models of single nucleotide polymorphisms (SNPs) and only dichotomous phenotypes, or depend on proprietary software. In contrast, EpiGEN supports SNP interactions of arbitrary order, produces realistic LD patterns, and can generate both categorical and quantitative phenotypes.

Publication
Bioinformatics
Date