A snapshot of a typical CoVex result showing virus-host-drug interactions.

The fight against COVID-19

The CoVex systems medicine platform

A snapshot of a typical CoVex result showing virus-host-drug interactions.

The fight against COVID-19

The CoVex systems medicine platform

To address the Coronavirus Disease-2019 (COVID-19) crisis, drug repurposing is an attractive approach that offers new therapeutic options through the identification of alternative usages for already approved drugs. Numerous research groups around the world are working on treatment options for COVID-19 and are joining efforts to identify drugs that can be repurposed. A promising strategy for identifying drugs is to use network and systems medicine approaches, which provide a comprehensive understanding of the infection mechanisms while not only focussing on the virus and its direct interaction partners, but also including the host protein interaction network. To aid in COVID-19 related drug repurposing, the Chair of Experimental Bioinformatics organized a hackathon to develop CoVex, a network and systems medicine platform that integrates virus-human interaction data for SARS-CoV-2 and SARS-CoV. CoVex supports researchers in interactive network medicine analysis, where they can bring in their expert knowledge to identify putative drug targets and drug repurposing candidates.

More information: https://www.exbio.de/exbio-vs-covid-part-1
The CoVex platform: https://exbio.wzw.tum.de/covex
Animation video:

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Markus List
Head of the Research Group Big Data in Biomedicine

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